Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma

Agababaoglu I., Onen A., Demir A. B., AKTAŞ S., ALTUN Z. S., Ersoz H., ...Daha Fazla

MEDICINE, cilt.96, sa.6, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1097/md.0000000000005903
  • Dergi Adı: MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: annexin-2, cancer screening, chaperonin, lung cancer, protemic, CANCER DETECTION, IDENTIFICATION, EXPRESSION, PROGRAM
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Lung cancer is responsible of 12.4% and 17.6% of all newly diagnosed cancer cases and mortality due to cancer, respectively, and 5-year survival rate despite all improved treatment options is 15%. This survival rate reaches 66% in the Stage 1 and surgically treated patients. Early diagnosis which could not be definitely and commonly achieved yet is extremely critical in obtaining high survival rate in this disease. For this reason; proteomic differences were evaluated using matrix assisted laser desorption ionization (MALDI) mass spectrometry in the subgroups of lung adenocarcinoma and squamous cell carcinoma.