BALB/C FARELERİNDE AKUT ÇİNKO SÜLFAT UYGULAMASININ DUYUSAL ALGILAMA, KAS GÜCÜ VE SİNİR İLETİM HIZI ÜZERİNDEKİ ZAMANA BAĞLI ETKİLERİ: ÖN ÇALIŞMA
FensForum, Barcelona, İspanya, 6 - 10 Temmuz 2026, (Yayınlanmadı)
- Yayın Türü: Bildiri / Yayınlanmadı
- Basıldığı Şehir: Barcelona
- Basıldığı Ülke: İspanya
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Abstract Body Abstract body: Introduction: Zinc is an essential trace element involved in neuromodulation and neuromuscular performance. While its chronic benefits are well documented, the immediate changes that occur over time following a single administration remain poorly understood. This study aimed to investigate how zinc sulfate affects locomotor activity, pain sensitivity, and peripheral nerve conduction at different time points. Methods: Adult BALB/c mice were administered a single dose of 50 mg/kg zinc sulfate. Evaluations were conducted at 30 minutes and 4 hours postadministration. Behavioral assessments included the open-field test for locomotor activity, grip-strength testing for motor performance, and the hot-plate test for thermal nociception. Electromyographic (EMG) recordings were performed to determine nerve conduction velocity (NCV). Results: Our findings showed that zinc sulfate prolonged hot-plate latency at both 30 minutes and 4 hours compared with the control group, suggesting a modulatory effect on sensory thresholds. Muscle strength increased at the 4-hour mark. Electrophysiological recordings revealed a decrease in NCV at 30 minutes post-administration compared to controls. Notably, no alterations in locomotor activity or exploratory behavior were observed in the open field test at any time point, suggesting that the changes in sensory and motor parameters were independent of general mobility. Conclusion: These preliminary findings suggest that acute zinc sulfate exposure leads to time-dependent variations in the nervous system. These are characterized by early shifts in nerve conduction and pain thresholds, followed by a later increase in muscle strength. This study highlights the importance of the time-course in physiological responses to zinc and provides a basis for further investigations