The association between serum vitamin B-12 deficiency and tension-type headache in Turkish children


Calik M., Aktas M. S., Cecen E., Piskin I. E., Ayaydin H., Ornek Z., ...More

NEUROLOGICAL SCIENCES, vol.39, no.6, pp.1009-1014, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1007/s10072-018-3286-5
  • Journal Name: NEUROLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1009-1014
  • Keywords: Vitamin B-12 deficiency, Headache, Depression, Anxiety, Children, CHILDHOOD HEADACHES, WEST SYNDROME, FOLIC-ACID, MIGRAINE, HOMOCYSTEINE, DEPRESSION, INFANTS, FOLATE, ADOLESCENTS, POPULATION
  • Dokuz Eylül University Affiliated: No

Abstract

This study aimed to determine the relationship between serum vitamin B12 level and tension-type headache. The study groups consisted of 75 patients (40 females, 35 males) with headache and a control group of 49 healthy children (25 females, 24 males). Serum vitamin B12 level < 200 pg/ml was defined as deficient, and < 160 pg/ml as severely deficient. The serum vitamin B12 level was measured by the electrochemiluminescence (ECLIA) method. The serum vitamin B12 levels in the headache and control groups were 273.01 +/- 76.77 and 316.22 +/- 74.53 pg/ml, with the difference determined as statistically significant (p = 0.003). In the case group, 18/75 patients (24%) had a serum vitamin B12 level below the normal of 200 pg/ml, and in the control group 4/49 (8%) patients were also below the normal range (p = 0.021). The serum vitamin B12 level in the children with tensiontype headache was significantly lower than that in the control group. Fromthe results of the study, itwas concluded that there may be an association between vitamin B12 level and tension-type headache. However, further clinical studies are needed.