Comparison of the hematological parameters of recurrent aphthous stomatitis and Behçet’s disease

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Avcı C., Akarsu S., Özbağçıvan Ö.

DERI HASTALIKLARI VE FRENGI ARSIVI, cilt.58, ss.35-41, 2024 (Scopus) identifier

Özet

Abstract

Background and Design: Hematological parameters have been used as laboratory markers to evaluate the systemic inflammation in several

rheumatic disease. The aim of this study is to determine the difference of hematological parameters between the patients who have been just

fulfilled the Behçet’s disease (BD) criteria and patients with recurrent aphthous stomatitis (RAS).

Materials and Methods: Twenty patients with newly diagnosed BD and 47 patients with RAS whose oral ulcerations appeared at least three

times a year were enrolled in this cross-sectional study. Demographic and clinical characteristics of patients, complete blood count, C-reactive

protein (CRP) and erythrocyte sedimentation rate were recorded.

Results: Patients’ characteristics including gender, age, duration, and frequency of oral aphthous ulcerations in both study groups were

comparable (p>0.05). CRP was significantly higher in newly diagnosed BD group when compared to the RAS group (p=0.001). CRP value

higher than 2.7 g/dL, mean platelet volume (MPV) value higher than 7.58 fL and lymphocyte count higher than 2.85 103/μL were found to

be the markers for distinguishing patients with BD from patients with RAS [odds ratio (OR): 12.76 (95% confidence interval (CI): 2.86-56.88),

OR: 5.61 (95% CI: 1.11-28.42), OR: 15.24 (95% CI: 1.77-131.31), respectively].

Conclusion: The elevated CRP, MPV and lymphocyte count were associated with patients with newly diagnosed BD rather than patients with

RAS. Further large prospective studies with the healthy control group are needed to confirm these findings.

Keywords: Behçet disease, recurrent aphthous stomatitis, blood cell count