Targeted Next-Generation Sequencing of MLH1, MSH2, and MSH6 Genes in Patients with Endometrial Carcinoma under 50 Years of Age

Ozdemir T. R., Alan M., Sanci M., Koc A.

BALKAN MEDICAL JOURNAL, vol.36, no.1, pp.37-42, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.4274/balkanmedj.2018.0922
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.37-42
  • Keywords: Endometrial carcinomas, Lynch syndrome, mismatch repair, sequence analysis, NONPOLYPOSIS COLORECTAL-CANCER, IDENTIFYING LYNCH SYNDROME, MEDICAL GENETICS, AMERICAN-COLLEGE, MISMATCH REPAIR, RISK-ASSESSMENT, GENOMICS, PREVALENCE, GUIDELINES, MUTATION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Lynch syndrome is an inherited cancer disorder that causes an increased lifetime risk of various types of cancers. Endometrial cancer is the most common extracolonic cancer in Lynch syndrome. Guidelines recommend that patients with endometrial cancer younger than 50 years of age should be evaluated for Lynch syndrome. Molecular analysis of the mismatch repair genes and EPCAM gene is required for a definitive diagnosis of Lynch syndrome.