Akademik Veri Yönetim Sistemi
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.82, sa.4, ss.565-578, 2025 (Scopus, TRDizin)
Objective: This study aims to describe characteristics of poisonings in patients who were treated with extracorporeal methods between January 01, 2011 and December 31, 2017 in Dokuz Eylul University Drug and Poison Information Center (DEUDPIC). Methods: This cross-sectional and descriptive study included patients who received extracorporeal treatment for poisoning. The data were obtained from the hospital automation system, extracorporeal treatment unit forms, and DEUDPIC forms. The severity was classified using the Poisoning Severity Score, and Glasgow Coma Scores (GCS) were recorded. Statistical analyses involved Kolmogorov-Smirnov tests for normality, Student’s t-test for parametric comparisons, and Mann-Whitney U test for non parametric data. Risk factors for mortality in specific common drug toxicities are determined using logistic regression analysis. Analyses were conducted using SPSS-24. Results: A total of 75 cases participated in the study. The mean age was 51.5±19.7 years, with 60% of cases being male. Methanol (37.3%), lithium (18.7%), carbamazepine (10.7%), and digoxin (6.7%) caused the most poisonings, respectively. Extracorporeal treatment was used for “increasing the elimination of the substance exposed” in 74.7% of the cases for “renal support” in 25.3%, and the method was hemodialysis in all. Specific antidote treatment was applied to 29.3% of all cases and 67.9% of methanol poisonings. The most common complication of hemodialysis was hypotension (28%). A majority of the patients (73.3%) necessitated intensive care unit support. Three patients recovered with sequelae (4%), and 21 (28%) died. Among patients who suffered from methanol poisoning, pH1.2 mg/dL, and lower GCS were associated with mortality in univariate analysis. In the multivariate regression analysis, the sole independent predictor of mortality was found to be the GCS (OR 0.62, 95% CI 0.39-0.99, p=0.05). Conclusion: Despite adequate hemodialysis, mortality rate is high in the setting of common drug poisonings. A low GCS is the only independent predictor of mortality in the setting of methanol poisoning.