New generation endo-cap approach for well-confined and angle-controlled laser coagulation of the esophageal mucosa and submucosa layers

TÜRKER BURHAN M., Altintas M., Ellidokuz E. B., TOZBURUN S.

37th Optical Interactions with Tissue and Cells, California, United States Of America, 17 - 18 January 2026, vol.13849, (Full Text)

  • Publication Type: Conference Paper / Full Text
  • Volume: 13849
  • Doi Number: 10.1117/12.3079176
  • City: California
  • Country: United States Of America
  • Keywords: angle-controlled therapy, confined therapy depth, endo-cap, endoscopy capsule, laser-induced therapy, Photothermal mucosa coagulation
  • Dokuz Eylül University Affiliated: Yes

Abstract

There are typically three treatment options for superficial abnormal mucosal tissue, such as Barrett's esophagus: medication, endoscopic procedures, and surgery. The choice of treatment depends on the severity of the condition. Among these options, endoscopic ablation techniques have gained recognition as the most effective. However, achieving the optimal depth of therapy to ensure complete eradication of lesions remains a significant challenge. Insufficient depth can lead to recurrence or allow lesions to remain hidden beneath healthy tissue, while excessive depth increases the risk of complications such as bleeding, perforation, or organ narrowing. In this study, we introduced a design for an endocap that efficiently confines laser energy within a recessed channel. This design allows for precise angular control, enabling well-defined radial coagulation of the esophageal mucosal tissue. To implement this design, we used a specially crafted rigid insertion tube for accurate photothermal coagulation of the mucosal tissue. The endocap is equipped with a GRIN lens, a stepper motor, and gold-coated right-angle prism mirrors. We conducted tests at various laser scanning speeds and rotation angles while sliding the cap over the surface of a sheep esophagus model. Our findings suggest that this endocap design has the potential to yield more effective and safer treatment options for superficial esophageal abnormalities.