Akademik Veri Yönetim Sistemi
Monatshefte fur Chemie, cilt.157, sa.2, ss.239-249, 2026 (SCI-Expanded, Scopus)
Acyclovir is an important drug that needs to be monitored for accumulation or misuse, especially in people on antiviral therapy. Therefore, it is important to design a sensitive and selective electrode for the determination of acyclovir. In this study, a novel NH2-functionalized graphene oxide-modified glassy carbon electrode (NH2-GO/GCE) was developed for the sensitive and accurate determination of acyclovir. NH2-GO was synthesized by a simple amination method, and the sensor surface was formed by drop-casting it onto the GCE surface. NH2 groups accelerated electron transfer by the electrochemical response of the modified electrode compared to GO and contributed to stronger interactions with the analyte. In this way, the developed NH2-GO/GCE sensor showed high sensitivity and selectivity in acyclovir determination. The detection limit was determined as 9.2 nmol dm−3 and a wide linear range between 0.03 and 500 µmol dm−3 was obtained. The applicability of the NH2-GO/GCE sensor was tested on pharmaceutical tablet samples and satisfactory recovery rates were obtained. Furthermore, the developed sensor retained more than 92% of the initial response after 15 days and showed relative standard deviation (RSD) values below 4.5%. This demonstrated the storage stability and reproducibility of the sensor.