New alterations at potentially regulated regions of the Glial Derived Neurotrophic Factor gene in bipolar disorder

Safari, Roghaiyeh; Tunca, Zeliha; Ozerdem, Aysegul; Ceylan, Deniz; ERESEN YAZICIOĞLU, ÇİĞDEM; Sakizli, Meral

doi:10.1016/j.jad.2014.06.002

New alterations at potentially regulated regions of the Glial Derived Neurotrophic Factor gene in bipolar disorder

Safari R., Tunca Z., Ozerdem A., Ceylan D., ERESEN YAZICIOĞLU Ç., Sakizli M.

JOURNAL OF AFFECTIVE DISORDERS, cilt.167, ss.244-250, 2014 (SCI-Expanded, SSCI, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 167
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.jad.2014.06.002
Dergi Adı: JOURNAL OF AFFECTIVE DISORDERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Sayfa Sayıları: ss.244-250
Anahtar Kelimeler: GDNF, Bipolar disorder, SNP
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: Glial Derived Neurotrophic Factor (GDNF) plays an important role in the survival and differentiation of neurons. We examined 5'upstream and 3' untranslated region of the GDNF gene by PCR amplification and direct sequencing to explore the effect of alteration in the potentially regulated part of GDNF in bipolar disorder.