New alterations at potentially regulated regions of the Glial Derived Neurotrophic Factor gene in bipolar disorder

Safari, Roghaiyeh; Tunca, Zeliha; Ozerdem, Aysegul; Ceylan, Deniz; ERESEN YAZICIOĞLU, ÇİĞDEM; Sakizli, Meral

doi:10.1016/j.jad.2014.06.002

New alterations at potentially regulated regions of the Glial Derived Neurotrophic Factor gene in bipolar disorder

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Safari R., Tunca Z., Ozerdem A., Ceylan D., ERESEN YAZICIOĞLU Ç., Sakizli M.

JOURNAL OF AFFECTIVE DISORDERS, vol.167, pp.244-250, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 167
Publication Date: 2014
Doi Number: 10.1016/j.jad.2014.06.002
Journal Name: JOURNAL OF AFFECTIVE DISORDERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Page Numbers: pp.244-250
Keywords: GDNF, Bipolar disorder, SNP, COMORBIDITY SURVEY REPLICATION, GENDER-DIFFERENCES, MOOD DISORDERS, ONSET, AGE, GDNF, PREVALENCE, EXPRESSION, SEQUENCES, LIFETIME
Dokuz Eylül University Affiliated: Yes

Abstract

Introduction: Glial Derived Neurotrophic Factor (GDNF) plays an important role in the survival and differentiation of neurons. We examined 5'upstream and 3' untranslated region of the GDNF gene by PCR amplification and direct sequencing to explore the effect of alteration in the potentially regulated part of GDNF in bipolar disorder.