Aim. The aim is to examine the effects of hyperglycemic (hg) regulation on the morbidity of diabetic patients after above knee femoro-popliteal bypass surgery. Methods. Thirtynine diabetic cases underwent above knee F-P bypass surgery from January, 1997 to December 2002 in the Department of Cardiovascular Surgery, Alsancak State Hospital, Izmir. In every patient, autogenous saphenous vein graft was used. The patients were classified into two groups according to the posology of intraoperative and postoperative intravenous insuline infusion. The posology of the first group consisting of 20 patients were regulated in consistency with the Portland Protocole. In the second group including 19 patients, intravenous bolus insuline was administered in order to maintain an average blood glucose level of 150-200 mg/dl, in cases of exceeding levels of 200 mg/dl. The mean blood glucose level was above 200 mg/dl in group I, in spite of the protocole. Results. Accepting postoperative 30 days as the early period, four superficial wound infections and two seromas in the femoral area were observed in group I. The number of cases subjected to these morbidity factors was significantly lower, being one and one patient respectively in group II. Conclusion. When the risk factors for postoperative wound infection are equalized among two groups, we believe that administration of intravenous insuline infusion, along with additional IV bolus insuline in case of necessity, will lower the incidence of infection.