Akademik Veri Yönetim Sistemi
Interdisciplinary Cancer Research, Nima Rezaei, Editör, Springer, London/Berlin , Edinburgh, ss.1-32, 2024
Natural killer/T cell lymphoma (NKTCL), as an invasive subtype of non-Hodgkin lymphoma, is tightly linked with Epstein-Barr virus (EBV) infection. Genomic and epigenomic aberrations might be responsible for distinct hallmarks and pathogenic mechanisms of NKTCL through dysregulation of the expression of key genes, including EBV-associated epigenetic drivers. The genomic pattern of NKTCL was elucidated using next-generation sequencing (NGS) analysis methodologies, which revealed the aberrations of epigenetic regulators, JAK/STAT pathway, RAS/MAPK pathway, RNA helicase family members, and tumor suppressors. Epigenetic alterations predominantly include dysregulation of histone modifications, DNA methylation, and noncoding RNAs. Promoter hypermethylation-induced inactivation of tumor suppressor genes is found in NKTCL patients, further causing pathogenesis via global alteration of chromatin states. Noncoding RNAs mainly including host cell miRNAs, lncRNAs, and EBV-expressed miRNAs have been identified to be abnormally expressed in NKTCL. Herein, we comprehensively shed light on genomic and epigenomic abnormalities in NKTCL to deepen the elucidation of NKTCL pathobiology. Furthermore, the potential of genomic and epigenomic aberrations is also elaborated in this chapter to provide novel insights on improved diagnosis, prognostication as well as discovery of novel therapeutic targets for NKTCL.