Gemcitabine plus infusional 5-fluorouracil and high dose leucovorin in advanced stage pancreatic cancer
JOURNAL OF BUON, cilt.15, sa.3, ss.462-469, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 3
- Basım Tarihi: 2010
- Dergi Adı: JOURNAL OF BUON
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.462-469
- Anahtar Kelimeler: advanced stage, 5-fluorouracil, gemcitabine, pancreatic cancer
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Purpose: Advanced pancreatic cancer (APC) has a poor prognosis and chemotherapy remains the primary treatment modality. Gemcitabine (GEM) and 5-fluorouracil (5-FU) are the most active drugs in the treatment of pancreatic cancer This study evaluated the efficacy and tolerability of the combination of these agents in APC. Methods: Forty-four patients with APC were treated with GEM and infusional 5-FU with high dose leucovorin (LV5FU2) (GEMFUFOL regimen). Results: A total of 240 chemotherapy cycles were administered. The overall response rate was 27.2%, and all responses were partial. Furthermore, disease stabilization was observed in 12 patients (27.2%). Median survival time and one-year survival rate were 9 months and 36.4%, respectively The overall grade 3 or 4 adverse events were very low and mostly hematological. Conclusion: GEMFUFOL is still an active regimen for the treatment of APC and has an acceptable toxicity.