Effect of subminimal inhibitory concentrations of three fluoroquinolones on adherence of uropathogenic strains of Escherichia coli.


BASKIN A. H., Dogan Y., Bahar I., Yulug N.

International journal of antimicrobial agents, vol.19, no.1, pp.79-82, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1016/s0924-8579(01)00469-1
  • Journal Name: International journal of antimicrobial agents
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.79-82
  • Keywords: SubMIC, uropathogenic Escherichia coli, quinolones, adherence, SUBINHIBITORY CONCENTRATIONS, ANTIBIOTICS, HEMAGGLUTINATION, COLONIZATION, INFECTIONS, MECHANISMS, ABSENCE, MANNOSE
  • Dokuz Eylül University Affiliated: Yes

Abstract

The effect of subinhibitory concentrations (1/2-1/32 x MIC) of ciprofloxacin, ofloxacin and levofloxacin on the adherence of three strains of Escherichia coli (a mannose-resistant haemagglutinating clinical isolate, a non-haemagglutinating clinical isolate and the mannose-resistant haemagglutinating ATCC 25922 strain) were studied. Ciprofloxacin had the lowest MIC values but only the 1/2 MIC concentration inhibited adherence of mannose-resistant haemagglutinating strains after exposure to subMIC values. Significant inhibition of adherence was observed with 1/4 x MIC ofloxacin for both haemagglutinating isolate (27096) and the ATCC strain. Levofloxacin might be more effective and safer than ciprofloxacin and ofloxacin as a long acting fluoroquinolone at subMIC values in patients with UTI. (C) 2002 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.