Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

Kotseva, Kornelia; Mirrakhimov, Erkin; Rydén, Lars; Wood, David; De Backer, G.; De Backer, G.; Jankowski, P.; Jankowski, P.; Kotseva, K.; Mirrakhimov, E.; Rydén, L.; Tokgözoğlu, L.; Tokgözoğlu, L.; Wood, D.; Abreu, A.; Aguiar, C.; Badariene, J.; Bruthans, J.; Castro Conde, A.; Cifkova, R.; Crowley, J.; Davletov, K.; de Bacquer, D.; de Bacquer, D.; de Bacquer, D.; De Smedt, D.; De Sutter, J.; Deckers, J.W.; Dilic, M.; Dolzhenko, M.; Druais, H.; Dzerve, V.; Erglis, A.; Fras, Z.; Gaita, D.; Gotcheva, N.; Grobbee, D.E.; Gyberg, V.; Hasan-Ali, H.; Heuschmann, P.; Hoes, A.W.; Lalic, N.; Lehto, S.; Lovic, D.; Maggioni, A.P.; Mancas, S.; Marques-Vidal, P.; Mellbin, L.; Oganov, R.; Pogosova, N.; Reiner, Ž.; Reiner, Ž.; Reiner, Ž.; Stagmo, M.; Störk, S.; Sundvall, J.; Tsioufis, K.; Vulic, D.; Wood, D.A.; Jennings, C.; Adamska, A.; Adamska, S.; Tuomilehto, J.; Schnell, O.; Fiorucci, E.; Glemot, M.; Larras, F.; Missiamenou, V.; Maggioni, A.; Taylor, C.; Ferreira, T.; Lemaitre, K.; Raman, L.; DeSmedt, D.; Willems, A.M.; De Pauw, M.; Vervaet, P.; Bollen, J.; Dekimpe, E.; Mommen, N.; Van Genechten, G.; Dendale, P.; Bouvier, C.A.; Chenu, P.; Huyberechts, D.; Persu, A.; Begic, A.; Durak Nalbantic, A.; Dzubur, A.; Hadzibegic, N.; Iglica, A.; Kapidjic, S.; Osmanagic Bico, A.; Resic, N.; Sabanovic Bajramovic, N.; Zvizdic, F.; Kovacevic-Preradovic, T.; Popovic-Pejicic, S.; Djekic, D.; Gnjatic, T.; Knezevic, T.; Kos, Lj; Stanetic, B.; Topic, G.; Georgiev, Borislav; Terziev, A.; Vladimirov, G.; Angelov, A.; Kanazirev, B.; Nikolaeva, S.; Tonkova, D.; Vetkova, M.; Milicic, D.; Milicic, D.; Bosnic, A.; Dubravcic, M.; Glavina, M.; Mance, M.; Pavasovic, S.; Samardzic, J.; Batinic, T.; Crljenko, K.; Delic-Brkljacic, D.; Dula, K.; Golubic, K.; Klobucar, I.; Kordic, K.; Kos, N.; Nedic, M.; Olujic, D.; Sedinic, V.; Blazevic, T.; Pasalic, A.; Percic, M.; Sikic, J.; Cífková, R.; Hašplová, K.; Šulc, P.; Wohlfahrt, P.; Mayer, O.; Cvíčela, M.; Filipovský, J.; Gelžinský, J.; Hronová, M.; Bakery, S.; Mosad, E.; Hamed, H.B.; Ibrahim, A.; Elsharef, M.A.; Kholef, E.F.; Shehata, A.; Youssef, M.; Elhefny, E.; Farid, H.; Moustafa, T.M.; Sobieh, M.S.; Kabil, H.; Abdelmordy, A.; Kiljander, E.; Kiljander, P.; Koukkunen, H.; Mustonen, J.; Cremer, C.; Frantz, S.; Haupt, A.; Hofmann, U.; Ludwig, K.; Melnyk, H.; Noutsias, M.; Karmann, W.; Prondzinsky, R.; Herdeg, C.; Hövelborn, T.; Daaboul, A.; Geisler, T.; Keller, T.; Sauerbrunn, D.; Walz-Ayed, M.; Ertl, G.; Leyh, R.; Ehlert, T.; Klocke, B.; Krapp, J.; Ludwig, T.; Käs, J.; Starke, C.; Ungethüm, K.; Wagner, M.; Wiedmann, S.; Tolis, P.; Vogiatzi, G.; Sanidas, E.; Tsakalis, K.; Kanakakis, J.; Koutsoukis, A.; Vasileiadis, K.; Zarifis, J.; Karvounis, C.; Gibson, I.; Houlihan, A.; Kelly, C.; O'Donnell, M.; Bennati, M.; Cosmi, F.; Mariottoni, B.; Morganti, M.; Cherubini, A.; Di Lenarda, A.; Radini, D.; Ramani, F.; Francese, M.G.; Gulizia, M.M.; Pericone, D.; Aigerim, K.; Zholdin, B.; Amirov, B.; Assembekov, B.; Chernokurova, E.; Ibragimova, F.; Kodasbayev, A.; Markova, A.; Asanbaev, A.; Toktomamatov, U.; Tursunbaev, M.; Zakirov, U.; Abilova, S.; Arapova, R.; Bektasheva, E.; Esenbekova, J.; Neronova, K.; Baigaziev, K.; Baitova, G.; Zheenbekov, T.; Andrejeva, T.; Bajare, I.; Kucika, G.; Labuce, A.; Putane, L.; Stabulniece, M.; Klavins, E.; Sime, I.; Gedvilaite, L.; Pečiuraite, D.; Sileikienė, V.; Skiauteryte, E.; Solovjova, S.; Sidabraite, R.; Briedis, K.; Ceponiene, I.; Jurenas, M.; Kersulis, J.; Martinkute, G.; Vaitiekiene, A.; Vasiljevaite, K.; Veisaite, R.; Plisienė, J.; Šiurkaitė, V.; Vaičiulis, Ž.; Czarnecka, D.; Kozieł, P.; Podolec, P.; Nessler, J.; Gomuła, P.; Mirek-Bryniarska, E.; Bogacki, P.; Wiśniewski, A.; Pająk, A.; Wolfshaut-Wolak, R.; Bućko, J.; Kamiński, K.; Łapińska, M.; Paniczko, M.; Raczkowski, A.; Sawicka, E.; Stachurska, Z.; Szpakowicz, M.; Musiał, W.; Dobrzycki, S.; Bychowski, J.; Kosior, D.A.; Krzykwa, A.; Setny, M.; Rak, A.; Gąsior, Z.; Haberka, M.; Szostak-Janiak, K.; Finik, M.; Liszka, J.; Botelho, A.; Cachulo, M.; Sousa, J.; Pais, A.; Durazzo, A.; Matos, D.; Gouveia, R.; Rodrigues, G.; Strong, C.; Guerreiro, R.; Aguiar, J.; Cruz, M.; Daniel, P.; Morais, L.; Moreira, R.; Rosa, S.; Rodrigues, I.; Selas, M.; Apostu, A.; Cosor, O.; Gaita, L.; Giurgiu, L.; Hudrea, C.; Maximov, D.; Moldovan, B.; Mosteoru, S.; Pleava, R.; Ionescu, M.; Parepa, I.; Arutyunov, A.; Ausheva, A.; Isakova, S.; Karpova, A.; Salbieva, A.; Sokolova, O.; Vasilevsky, A.; Pozdnyakov, Y.; Antropova, O.; Borisova, L.; Osipova, I.; Aleksic, M.; Crnokrak, B.; Djokic, J.; Hinic, S.; Vukasin, T.; Zdravkovic, M.; Lalic, N.M.; Jotic, A.; Lalic, K.; Lukic, L.; Milicic, T.; Macesic, M.; Stanarcic Gajovic, J.; Stoiljkovic, M.; Djordjevic, D.; Kostic, S.; Tasic, I.; Vukovic, A.; Jug, B.; Juhant, A.; Krt, A.; Kugonjič, U.; Chipayo Gonzales, D.; Gómez Barrado, J.J.; Kounka, Z.; Marcos Gómez, G.; Mogollón Jiménez, M.V.; Ortiz Cortés, C.; Perez Espejo, P.; Porras Ramos, Y.; Colman, R.; Delgado, J.; Otero, E.; Pérez, A.; Fernández-Olmo, M.R.; Torres-LLergo, J.; Vasco, C.; Barreñada, E.; Botas, J.; Campuzano, R.; González, Y.; Rodrigo, M.; de Pablo, C.; Velasco, E.; Hernández, S.; Lozano, C.; González, P.; Castro, A.; Dalmau, R.; Hernández, D.; Irazusta, F.J.; Vélez, A.; Vindel, C.; Gómez-Doblas, J.J.; García Ruíz, V.; Gómez, L.; Gómez García, M.; Jiménez-Navarro, M.; Molina Ramos, A.; Marzal, D.; Martínez, G.; Lavado, R.; Vidal, A.; Boström-Nilsson, V.; Kjellström, B.; Shahim, B.; Smetana, S.; Hansen, O.; Stensgaard-Nake, E.; Klijn, A.J.; Mangus, T.J.P.; Peters, R.J.G.; Scholte op Reimer, W.; Snaterse, M.; Aydoğdu, S.; Ç Erol, Erol; Otürk, S.; Tulunay Kaya, C.; Ahmetoğlu, Y.; Ergene, O.; Akdeniz, BAHRİ; Çırgamış, D.; Akkoyun H Kültürsay, S.; Kayıkçıoğlu, M.; Çatakoğlu, A.B.; Çengel, A.; Koçak, A.A.; Ağırbaşlı, M.A.; Açıksarı, G.; Çekin, M.E.; Kaya, E.B.; Koçyiğit, D.; Öngen, Z.; Özmen, E.; Sansoy, V.; Kaya, A.; Oktay, V.; Temizhan, A.; Ünal, S.; İ Yakut, Yakut; Kalkan, A.K.; Bozkurt, E.; Kasapkara, H.A.; Faradzh, C.; Hrubyak, L.; Konoplianyk, L.; Kozhuharyova, N.; Lobach, L.; Nesukai, V.; Nudchenko, O.; Simagina, T.; Yakovenko, L.; Azarenko, V.; Potabashny, V.; Bazylevych, A.; Bazylevych, M.; Kaminska, K.; Panchenko, L.; Shershnyova, O.; Ovrakh, T.; Serik, S.; Kolesnik, T.; Kosova, H.; Hoye P Atkin, A.; Fellowes, D.; Lindsay, S.; Atkinson, C.; Kranilla, C.; Vinod, M.; Beerachee, Y.; Bennett, C.; Broome, M.; Bwalya, A.; Caygill, Lindsay; Dinning, L.; Gillespie, A.; Goodfellow, R.; Guy, J.; Idress, T.; Mills, C.; Morgan, C.; Oustance, N.; Singh, N.; Yare, M.; Jagoda, J.M.; Bowyer, H.; Christenssen, V.; Groves, A.; Jan, A.; Riaz, A.; Gill, M.; Sewell, T.A.; Gorog, D.; Baker, M.; De Sousa, P.; Mazenenga, T.; Porter, J.; Haines, F.; Peachey, T.; Taaffe, J.; Wells, K.; Ripley, D.P.; Forward, H.; McKie, H.; Pick, S.L.; Thomas, H.E.; Batin, P.D.; Exley, D.; Rank, T.; Wright, J.; Kardos, A.; Sutherland, S.-B.; Wren, L.; Leeson, P.; Barker, D.; Moreby, B.; Sawyer, J.; Stirrup, J.; Brunton, M.; Brodison, A.; Craig, J.; Peters, S.; Kaprielian, R.; Bucaj, A.; Mahay, K.; Oblak, M.; Gale, C.; Pye, M.; McGill, Y.; Redfearn, H.; Fearnley, M.

doi:10.1016/j.atherosclerosis.2019.03.014

Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

Kotseva K., Mirrakhimov E., Rydén L., Wood D., De Backer G., De Backer G., ...Daha Fazla

Atherosclerosis, cilt.285, ss.135-146, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 285
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.atherosclerosis.2019.03.014
Dergi Adı: Atherosclerosis
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.135-146
Anahtar Kelimeler: LDL-Cholesterol, Coronary heart disease, EUROASPIRE, Secondary prevention, Dyslipidaemia, Lipid lowering therapy
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background and aims: One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. Methods: Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT. Results: At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes. Conclusions: The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.