Structural brain changes in bipolar disorder using deformation field morphometry

Soares J., Kochunov P., Monkul E., Nicoletti M., Brambilla P., Sassi R., ...More

NEUROREPORT, vol.16, no.6, pp.541-544, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1097/00001756-200504250-00004
  • Journal Name: NEUROREPORT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.541-544
  • Keywords: bipolar disorder, mood disorders, magnetic resonance imaging, morphometry, neuroimaging, structural, REGIONAL SPATIAL NORMALIZATION, VENTRICULAR ENLARGEMENT, MOOD DISORDERS, SCHIZOPHRENIA, ABNORMALITIES, TARGET, MRI
  • Dokuz Eylül University Affiliated: No

Abstract

The objective of this study was to investigate anatomical brain abnormalities in adult bipolar patients using a deformation field morphometry technique. Our sample consisted of 32 right-handed bipolar I patients (men/women=16/16) and 32 right-handed, age and gender matched healthy controls. Deformation field morphometry analysis was performed on three-dimensional spoiled gradient recalled acquisition images. We found genderspecific structural differences between bipolar patients and healthy individuals. Bipolar men had significantly larger lateral ventricles (especially pronounced in the left hemisphere) and smaller left dorsolateral prefrontal cortex than healthy male controls. Our results are complementary to the findings of functional imaging and post-mortem studies that demonstrate abnormalities in the dorsolateral prefrontal cortex in bipolar patients.© 2005 Lippincott Williams & Wilkins.