Age-dependent effects of maternal deprivation on oxidative stress in infant rat brain

UYSAL HARZADIN N., Gonenc S., Acikgoz O., Petcetin Ç., Kayatekin B. M., Sonmez A., ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.384, sa.1-2, ss.98-101, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 384 Sayı: 1-2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.neulet.2005.04.052
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.98-101
  • Anahtar Kelimeler: maternal deprivation, stress-hyporesponsive period, oxidative stress, prefrontal cortex, hippocampus, striatum and lipid peroxidation, GLUTATHIONE-PEROXIDASE ACTIVITY, SUPEROXIDE-DISMUTASE, DOPAMINE TURNOVER, NERVOUS-SYSTEM, SEPARATION, STRIATUM, PERIODS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Developing brain is much more sensitive to all kind of stressors. than the developed brain. Early maternal deprivatit in causes some behavioural and physiological effects on rats. After the birth, there is no endocrinological response to stressors between post-natal 4 and 14th days, which is called stress-hyporesponsive period (SHRP) in rats. This hypo-responsiveness is time- and stressor-specific, its some more severe stressors have been shown to induce a stress response. The present study examined the effects of maternal deprivation on oxidative stress in the hippocampus, prefrontal cortex (PFC) and striatum regions of the brain both during and after SHRP of the infant rats. The results showed that maternal deprivation in SHRP increased antioxidant enzyme activities and reduced lipid peroxidation in infant rat brain. However. by the termination of SHRP, maternal deprivation reduced enzyme activities and increased lipid peroxidation. The results indicated that infant brain might be protected in SHRP from maternal deprivation-induced oxidative stress. (c) 2005 Elsevier Ireland Ltd. All rights reserved.