BRAIN RESEARCH, cilt.1876, 2026 (SCI-Expanded, Scopus)
Alpha-band power is considered as a marker of sensory processing-related cortical states, including sensory suppression and the temporal organization of sensory input. This study aimed to investigate whether alpha-band power of electrophysiological brain responses is modulated by different interstimulus intervals during repetitive, non-painful tactile stimulation. Non-painful tactile stimuli were delivered to the index finger of the right hand with different interstimulus intervals (ISI) of 2 s (s), 4 s, and 8 s via a pneumatic stimulator. A separate session was conducted for each ISI in a pseudorandomized order. The electroencephalogram was recorded in all sessions with 24 volunteers. The results of the analysis showed that the alpha activity was lowest at ISI4 and highest at ISI8. This pattern was consistently observed in both the central and parietal regions. In the ISI2 session, although no notable variation among the frontal, central, and parietal areas was observed, the most pronounced activity was observed in the frontal region in the ISI4 session. The highest level of alpha activity was observed in the central area during the ISI8 session. Variations in interstimulus intervals affect inhibitory control and sensory processing in the brain. The frontal cortex appears to manage attention and cognitive control more efficiently at intermediate intervals (ISI4), whereas the central region shows greater involvement in processing tactile inputs at longer intervals (ISI8).