Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin

Cecen E., Ercetin P., KIRKIM G., Pamukoğlu A., AKTAŞ S., ALTUN Z. S., ...Daha Fazla

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, cilt.11, sa.1, ss.19-22, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/iao.2015.484
  • Dergi Adı: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.19-22
  • Anahtar Kelimeler: Cisplatin, sanguinarine, ototoxicity, HEI-OC1 cells, BCL-2 FAMILY PROTEINS, CANCER-CELLS, ALKALOID SANGUINARINE, INDUCED OTOTOXICITY, CHELERYTHRINE, DEATH, CYCLE, MODULATION, ACTIVATION, EXPRESSION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Sanguinarine is an alkaloid obtained from the root of Sanguinaria canadensis and other plants from the Papaveraceae family and is well known to possess a broad range of biological functions, such as antimicrobial, antifungal, anti-inflammatory, and antineoplastic activities. We aimed to specify the in vitro effect of sanguinarine on the House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and to compare this effect with the ototoxic effect of cisplatin (CDDP).