Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.11, no.1, pp.19-22, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 11 Issue: 1
- Publication Date: 2015
- Doi Number: 10.5152/iao.2015.484
- Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.19-22
- Keywords: Cisplatin, sanguinarine, ototoxicity, HEI-OC1 cells
- Dokuz Eylül University Affiliated: Yes
Abstract
OBJECTIVE: Sanguinarine is an alkaloid obtained from the root of Sanguinaria canadensis and other plants from the Papaveraceae family and is well known to possess a broad range of biological functions, such as antimicrobial, antifungal, anti-inflammatory, and antineoplastic activities. We aimed to specify the in vitro effect of sanguinarine on the House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and to compare this effect with the ototoxic effect of cisplatin (CDDP).