Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin

Cecen E., Ercetin P., KIRKIM G., Pamukoğlu A., AKTAŞ S., ALTUN Z. S., ...More

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.11, no.1, pp.19-22, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.5152/iao.2015.484
  • Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.19-22
  • Keywords: Cisplatin, sanguinarine, ototoxicity, HEI-OC1 cells, BCL-2 FAMILY PROTEINS, CANCER-CELLS, ALKALOID SANGUINARINE, INDUCED OTOTOXICITY, CHELERYTHRINE, DEATH, CYCLE, MODULATION, ACTIVATION, EXPRESSION
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVE: Sanguinarine is an alkaloid obtained from the root of Sanguinaria canadensis and other plants from the Papaveraceae family and is well known to possess a broad range of biological functions, such as antimicrobial, antifungal, anti-inflammatory, and antineoplastic activities. We aimed to specify the in vitro effect of sanguinarine on the House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and to compare this effect with the ototoxic effect of cisplatin (CDDP).