Research Information System
7. Uluslararası ve 18. Akademik Geriatri Kongresi, İzmir, Turkey, 22 September 2023 - 19 October 2025, pp.35-36, (Summary Text)
Introduction and Objective: Dementia with Lewy bodies (DLB) is one of the most common types of neurodegenerative dementias after Alzheimer Disease. In addition to dementia, distinguishing clinical features are dysautonomia and movement disorder. It is known that orthostatic hypotension, especially considered within the scope of dysautonomia, is associated with frailty, falls, mortality and morbidity. One of the important consequences of falling is fragility fractures that may occur due to osteoporosis. In this study, the relationship between DLB and osteoporosis was examined. Materials and Methods: 35 patients with a diagnosis of DLB and 85 cognitively healthy controls without acute problems who applied to Dokuz Eylul University Department of Geriatrics between February 2017 and December 2022 were examined. The groups were compared according to their demographic characteristics, comorbid conditions, and laboratory values. Results: The frequency of osteoporosis was 36.5% in the control group and 48.6% in the DLB group. (p=0.219) The average age was found to be higher in the DLB group (p=0.025). Female gender frequency, years of education and eGFR (estimated Glomerular Filtration Rate) levels were higher in the control group (p<0.05). Although the risk of osteoporosis increased in the DLB group, when regression analysis was performed according to age, gender, years of education and eGFR, this risk was not statistically significant. (OR:1.640, 95%CI 0.632-4.253, p= 0.309). Conclusion: Osteoporosis is an important health problem in advanced age due to fragility fractures that may occur as a result of falling. Evaluation of osteoporosis in DLB, which may predispose to falls due to dysautonomia, is crucial to prevent irreversible consequences. Although the risk and frequency of osteoporosis were found to be increased in DLB in our study, this risk was not statistically significant. Further studies with larger study groups are needed to elucidate this relationship.