Epidemiology and risk factors for invasive candidiasis

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Yapar N.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT, vol.10, pp.95-105, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 10
  • Publication Date: 2014
  • Doi Number: 10.2147/tcrm.s40160
  • Journal Name: THERAPEUTICS AND CLINICAL RISK MANAGEMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.95-105
  • Keywords: candidemia, invasive candidiasis, incidence, species distribution, risk factors, BLOOD-STREAM INFECTIONS, INTENSIVE-CARE-UNIT, NATIONWIDE SENTINEL SURVEILLANCE, POPULATION-BASED SURVEILLANCE, CHANGING EPIDEMIOLOGY, SPECIES DISTRIBUTION, ANTIFUNGAL SUSCEPTIBILITY, FUNGAL-INFECTIONS, HEMATOLOGIC MALIGNANCIES, CANDIDEMIA
  • Dokuz Eylül University Affiliated: Yes

Abstract

The number of immunosuppressive patients has increased significantly in recent years. These patients are at risk for opportunistic infections, especially fungal infections. Candidiasis is one of the most frequent fungal infections determined in these immunosuppressive patients and its epidemiology has changed over the last two decades. Recently, new antifungal agents and new therapy strategies such as antifungal prophylaxis, secondary prophylaxis, and preemptive therapy have come into use. These changes resulted in the alteration of Candida species causing invasive infections. The incidence of Candida albicans was decreased in many countries, especially among patients with immunosuppressive disorders, while the incidence of species other than C. albicans was increased. In this review, incidence, risk factors, and species distribution of invasive candidiasis are discussed.