Nivolumab-associated IgA Nephropathy in a Child With Malignant Melanoma

Yildiz G., TORUN BAYRAM M., Unlu S. M., SOYLU A., KAVUKÇU S., Olgun N.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.46, sa.7, 2024 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 7
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1097/mph.0000000000002931
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, MEDLINE
  • Anahtar Kelimeler: immune checkpoint inhibitor, nivolumab, IgA nephropathy, immune-related adverse event, acute interstitial nephritis
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Immune checkpoint inhibitors are humanized antibodies that inhibit downregulatory receptors on T cells, enhancing the antitumor activity of these cells. However, they have been associated with a wide range of systemic immune-related adverse events, including renal toxicities, among others. Most renal immune-related adverse events are acute interstitial nephritis causing acute kidney injury. Recently, immune checkpoint inhibitors-associated glomerular diseases, including IgA nephropathy, have been reported in adults. Most of the adult cases with glomerular involvement had also concomitant acute interstitial nephritis and acute kidney injury. We present the first pediatric case of IgA nephropathy without acute kidney injury during nivolumab treatment.