Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, cilt.1574, sa.3, ss.407-411, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1574 Sayı: 3
- Basım Tarihi: 2002
- Doi Numarası: 10.1016/s0167-4781(01)00319-0
- Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.407-411
- Anahtar Kelimeler: galectin, placenta, nuclear localization signal, unigene
- Dokuz Eylül Üniversitesi Adresli: Hayır
Özet
A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in he-art, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2. (C) 2001 Elsevier Science B.V. All rights reserved.