The Levels of Soluble CD40 Ligand and C-Reactive Protein in Normal Weight, Overweight and Obese People

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ÜNEK İ. T., BAYRAKTAR F., Solmaz D., ELLİDOKUZ H., Sisman A., YÜKSEL F., ...More

CLINICAL MEDICINE & RESEARCH, vol.8, no.2, pp.89-95, 2010 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.3121/cmr.2010.889
  • Journal Name: CLINICAL MEDICINE & RESEARCH
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.89-95
  • Keywords: Body mass index, CD40 ligand, C-reactive protein, Inflammation, Obesity
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Obesity has been suggested as an independent risk factor for cardiovascular disease. Increasing evidence shows that engagement of soluble CD40 ligand (sCD40L) with its receptor plays a crucial role in the pathogenesis of atherosclerosis. The aim of the present study was to test whether obesity is associated with low-grade systemic inflammation as measured by serum high-sensitive C-reactive protein (hsCRP) and sCD40L concentration.