Effects of <i>inactive parapoxvirus ovis</i> on cytokine levels in rats

Avci O., BULUT O., Dik I.

JOURNAL OF VETERINARY MEDICAL SCIENCE, vol.78, no.1, pp.129-131, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1292/jvms.15-0231
  • Journal Name: JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.129-131
  • Keywords: cytokine, inactive parapoxvirus ovis, rat
  • Dokuz Eylül University Affiliated: No

Abstract

The aim of this study is to determine the effects of iPPOV on pro-inflammatory and anti-inflammatory cytokine levels in rats. iPPOV (1 ml/rat) was administered intraperitoneal route to 49 rats, except for 7 rats (Control, 0 group). Serum samples were collected from 7 rats at 1st, 2nd, 4th, 8th, 12th, 16th and 24th hr after treatments. Levels of TNF-alpha, IL-6, IL-12 and IL-10 were determined using ELISA. Administration of iPPOV stimulated TNF-alpha (16th and 24th hr) and IL-6 (12th, 16th and 24th hr) synthesis and caused fluctuations in IL-10 and IL-12 concentrations. In conclusion, increased cytokine levels could be attributed to immunomodulatory activity of iPPOV, however, detailed studies are required to fully understand effects of iPPOV on immune system.