The effects of bee venom on liver and skeletal muscle in exhaustive swimming rats

Senturk A., Dalkiran B., Acikgoz B., AKSU İ., AÇIKGÖZ O., KİRAY M.

BIOLOGIA FUTURA, vol.73, no.2, pp.237-244, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1007/s42977-022-00115-6
  • Journal Name: BIOLOGIA FUTURA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.237-244
  • Keywords: Exhaustive exercise, Oxidative stress, Inflammation, Liver, Skeletal muscle, INDUCED CYTOGENETIC DAMAGE, LIPID-PEROXIDATION, OXIDATIVE STRESS, CONSTITUENT, EXPRESSION, ARTHRITIS, MELITTIN
  • Dokuz Eylül University Affiliated: Yes


Oxidative damage and proinflammatory cytokines are involved in exhaustive exercise-induced fatigue. This study aimed to investigate the effects of bee venom, a natural toxin, on fatigue and tissue damage in rats that underwent forced swimming exercise. Rats were divided into four groups: control, swimming exercise (SE), bee venom (BV) and swimming exercise + bee venom (SE + BV). SE and SE + BV groups were subjected to forced swimming (load of 7% body weight) for 5 days. BV and SE + BV groups were injected with 1 mg/kg BV subcutaneously. Swimming time, blood lactate and TNF-alpha levels, MDA and GSH levels in liver and gastrocnemius muscle were evaluated. Swimming time was shorter in SE + BV group than SE group. There was no difference in lactate levels between SE and SE + BV groups. MDA and GSH levels were increased in SE, BV and SE + BV groups. TNF-alpha levels were increased in BV group compared to control and SE groups. Our study demonstrated that BV administration before exhaustive exercise in rats did not provide anti-fatigue effect. Additionally, BV did not show anti-inflammatory activity and had different effects on antioxidant capacity at tissue level. Further research might explore the effects of different doses and durations of BV on exhaustive exercise.