Definitive radiotherapy for 114 cases of T3N0 glottic carcinoma: influence of dose-volume parameters on outcome

Wylie J., Sen M., Swindell R., Sykes A., Farrington W., Slevin N.

RADIOTHERAPY AND ONCOLOGY, vol.53, no.1, pp.15-21, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 1
  • Publication Date: 1999
  • Doi Number: 10.1016/s0167-8140(99)00131-0
  • Journal Name: RADIOTHERAPY AND ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.15-21
  • Keywords: radiotherapy, glottic, local control, regional control, volume, dose, SQUAMOUS-CELL CARCINOMA, ADVANCED LARYNGEAL-CANCER, NECK DISSECTION, TREATMENT TIME, LOCAL-CONTROL, CONVENTIONAL RADIOTHERAPY, RADIATION-THERAPY, HEAD, FRACTIONATION, MANAGEMENT
  • Dokuz Eylül University Affiliated: No

Abstract

Background and purpose: Assuming that the dose-response curve for T3N0M0 glottic carcinoma is steep and that the rate of occult lymph node metastases is low, it should be possible to employ high biological tumour doses to modest target volumes and thereby maximise laryngeal control without compromising final neck control. Within the constraints of a retrospective study we aim to examine this policy with respect to local control, incidence of nodal relapse and late complications.