UroVysion fluorescence in situ hybridization (UroVysion FISH) assay for detection of bladder cancer in voided urine of Turkish patients: a preliminary study

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DODURGA Y., BİRAY AVCI Ç., Yilmaz S., NAZLI O., ÇOĞULU M. Ö., ÇANKAYA T., ...More

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY, vol.17, no.2, pp.156-160, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.5114/wo.2013.34619
  • Journal Name: WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.156-160
  • Keywords: UroVysion FISH, bladder cancer, voided urine, cytology, TRANSITIONAL-CELL CARCINOMA, UROTHELIAL CARCINOMA, CYTOLOGY, MULTITARGET, SURVEILLANCE, UTILITY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Bladder cancer is the fourth most common cancer in men and the fifth most common cancer worldwide. UroVysion FISH has high sensitivity and specificity for urothelial carcinoma detection. We investigated the genetic marker detected by the UroVysion FISH technique in diagnosis of Turkish bladder cancer patients and compared these results with the urine cytology and cystoscopy. Urine specimens were analyzed using UroVysion FISH probes for abnormalities in centromeric chromosomes 3, 7, and 17 and locus-specific 9p21.