Social cognition in first-degree relatives of patients with bipolar disorder: A meta-analysis

BORA İ. E., Ozerdem A.

EUROPEAN NEUROPSYCHOPHARMACOLOGY, cilt.27, sa.4, ss.293-300, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.euroneuro.2017.02.009
  • Dergi Adı: EUROPEAN NEUROPSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.293-300
  • Anahtar Kelimeler: Bipolar disorder, Theory of mind, Familial, Cognition, Emotion recognition, Relatives, 1ST DEGREE RELATIVES, FACIAL EMOTION RECOGNITION, VERBAL WORKING-MEMORY, EUTHYMIC PATIENTS, 1ST-EPISODE SCHIZOPHRENIA, I DISORDER, HIGH-RISK, MIND, IMPAIRMENT, DEFICITS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Cognitive impairment is evident euthymic patients with bipolar disorder (BP) and in their first degree relatives (BP-Rel). Increasing evidence suggests that BP is also associated with social cognitive impairment. It is important to establish whether social cognitive impairment is also evident in BP-Rel. A novel meta-analysis of theory of mind (ToM) and facial emotion recognition in BP-Rel including 16 studies (728 first-degree relatives of patients with BP and 865 healthy controls) was conducted. ToM (d=0.34, CI=0.16-0.52) was significantly impaired in BP-Rel. The effect size for the difference between BP-Rel and healthy controls was smaller for facial emotion recognition (d=0.17, CI=0.16-0.29) and could be nonsignificant after the effect of publication bias was taken into account. First-degree relatives of patients with BP underperform healthy subjects in social cognitive abilities, particularly in ToM. However, the effect size for between-group difference is small. ToM impairment might be a vulnerability marker of BR (C) 2017 Elsevier B.V. and ECNP. All rights reserved.