Investigation of iron's neurotoxicity during cerebral maturation in the neonatal rat model of haemolysis

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Akar E., Unalp A., Diniz G., Ortac R., Senturk B., YILMAZ O., ...Daha Fazla

FOLIA NEUROPATHOLOGICA, cilt.53, sa.3, ss.262-269, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5114/fn.2015.54623
  • Dergi Adı: FOLIA NEUROPATHOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.262-269
  • Anahtar Kelimeler: haemolysis, neurotoxic, free iron, brain barrier systems, newborn, BILIRUBIN ENCEPHALOPATHY, PARKINSONS-DISEASE, BRAIN, METALS, HYPERBILIRUBINEMIA, MANGANESE, FERRITIN, DAMAGE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: Haemolytic disease of newborns due to rhesus and ABO incompatibility is encountered frequently in neonatal clinics and may lead to severe haemolysis. In this study, it is suggested that important amounts of iron released with haemolysis may have a toxic effect on the brain parenchymal tissue, and the severity of the toxic effect can be correlated with the maturation of the brain barrier systems. To demonstrate the accumulation and the neurotoxic effects of free iron (Fe) in the brain an experimental haemolysis model with various maturation phases was performed.