Investigation of iron's neurotoxicity during cerebral maturation in the neonatal rat model of haemolysis

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Akar E., Unalp A., Diniz G., Ortac R., Senturk B., YILMAZ O., ...More

FOLIA NEUROPATHOLOGICA, vol.53, no.3, pp.262-269, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.5114/fn.2015.54623
  • Journal Name: FOLIA NEUROPATHOLOGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.262-269
  • Keywords: haemolysis, neurotoxic, free iron, brain barrier systems, newborn, BILIRUBIN ENCEPHALOPATHY, PARKINSONS-DISEASE, BRAIN, METALS, HYPERBILIRUBINEMIA, MANGANESE, FERRITIN, DAMAGE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Introduction: Haemolytic disease of newborns due to rhesus and ABO incompatibility is encountered frequently in neonatal clinics and may lead to severe haemolysis. In this study, it is suggested that important amounts of iron released with haemolysis may have a toxic effect on the brain parenchymal tissue, and the severity of the toxic effect can be correlated with the maturation of the brain barrier systems. To demonstrate the accumulation and the neurotoxic effects of free iron (Fe) in the brain an experimental haemolysis model with various maturation phases was performed.