The aim of this study was to compare the apical leakage of roots filled with different materials using a computerized fluid filtration technique. There were 36 freshly extracted human maxillary central incisors selected. After preparation and irrigation, 3 experimental groups of 10 roots were constituted. Ten roots were filled with AH Plus and gutta-percha, 10 roots were filled with Sealapex and gutta-percha, and 10 roots were filled with Epiphany sealer and Resilon cone using a single cone technique. Three roots were used as a positive control and three roots were used as a negative control group. Evaluation of the apical leakages was performed with a computerized fluid filtration technique. According to the results, the difference between group 3 and 1 and group 3 and 2 was statistically significant (p < 0.05). Although group 2 leaked the most, there was no significant difference between group 1 and 2.