Apomorphine in the Treatment of Parkinson's Disease

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ÖZKAN S., Erer S., ELİBOL B., ÖZKAYNAK S. S., ÇAKMUR R., AKBOSTANCI M. C., ...More

TURKISH JOURNAL OF NEUROLOGY, vol.27, no.4, pp.358-365, 2021 (ESCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.4274/tnd.2021.06706
  • Journal Name: TURKISH JOURNAL OF NEUROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.358-365
  • Keywords: Apomorphine, Parkinson's disease, treatment
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: Yes

Abstract

Apomorphine is a dopamine agonist used in the treatment of some motor and non-motor complications during Parkinson's disease, which could be administered as an intermittent or continuous infusion. Although apomorphine treatment has been shown to be effective on motor fluctuations and dyskinesias, there is no sufficient consensus regarding the administration of apomorphine test or infusion, and the management of the treatment. In this review, our aim is to create a "treatment management guideline," which includes recommendations for the use of apomorphine in the clinical practice, and to discuss the problems encountered in both intermittent and continuous infusion applications, in the light of the literature.