AGE-RELATED DIGOXIN-ALPRAZOLAM INTERACTION


Güven H., Tunçok Y., Güneri S., Çavdar C., Fowler J.

CLINICAL PHARMACOLOGY & THERAPEUTICS, cilt.54, sa.1, ss.42-44, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1038/clpt.1993.107
  • Dergi Adı: CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.42-44
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpatients receiving long-term digoxin (0.25 mg daily) randomly received oral administration of either 1.0 or 0.5 mg alprazolam per day for 7 days. In each dosage group, three patients were older than and three were younger than 65 years of age. The area under the concentration-time curve for serum digoxin increased significantly in patients receiving 1 mg alprazolam daily, and this increase was more pronounced in patients older than 65 years of age. Clinical digoxin toxicity developed in one elderly patient who was receiving 1 mg/day alprazolam.