beta-blockers increase bone mineral density
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, sa.443, ss.73-74, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: Sayı: 443
- Basım Tarihi: 2006
- Doi Numarası: 10.1097/01.blo.0000200242.52802.6d
- Dergi Adı: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.73-74
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Authors of animal studies suggest that beta-blockers stimulate bone formation and inhibit bone resorption. On the other hand, data in humans are limited and conflicting results exist in literature. We conducted a prospective case-control study in order to investigate the effects of beta-blockers on bone mineral density in the elderly population. None of the patients were receiving anti-resorptive medicine. Bone mineral density of 50 beta-blocker users was significantly greater at all measured skeletal sites compared with 100 nonusers. Bone mineral density for total hip and spine (beta-blocker users and nonusers) were, 0.85 +/- 0.13, 0.80 +/- 0.11 and 0.90 +/- 0.15, 0.83 +/- 0.12, respectively. Our results suggest that use of beta-blockers is associated with an increase in bone mineral density.