beta-blockers increase bone mineral density

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Turker S., Karatosun V. A., Gunal I.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, no.443, pp.73-74, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: Issue: 443
• Publication Date: 2006
• Doi Number: 10.1097/01.blo.0000200242.52802.6d
• Journal Name: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.73-74
• Dokuz Eylül University Affiliated: Yes

Abstract

Authors of animal studies suggest that beta-blockers stimulate bone formation and inhibit bone resorption. On the other hand, data in humans are limited and conflicting results exist in literature. We conducted a prospective case-control study in order to investigate the effects of beta-blockers on bone mineral density in the elderly population. None of the patients were receiving anti-resorptive medicine. Bone mineral density of 50 beta-blocker users was significantly greater at all measured skeletal sites compared with 100 nonusers. Bone mineral density for total hip and spine (beta-blocker users and nonusers) were, 0.85 +/- 0.13, 0.80 +/- 0.11 and 0.90 +/- 0.15, 0.83 +/- 0.12, respectively. Our results suggest that use of beta-blockers is associated with an increase in bone mineral density.