The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance.

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ÜNLÜ Ş. M., Ozsan H., SARIOĞLU S.

Turkish journal of haematology : official journal of Turkish Society of Haematology, cilt.34, sa.4, ss.282-288, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjh.2017.0197
  • Dergi Adı: Turkish journal of haematology : official journal of Turkish Society of Haematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.282-288
  • Anahtar Kelimeler: Monoclonal gammopathy of renal significance, Plasma cell disorders, Multiple myeloma, Renal involvement, Kidney, Cast nephropathy, IMMUNOGLOBULIN DEPOSITION DISEASE, LIGHT-CHAIN DEPOSITION, CRYSTAL-STORING HISTIOCYTOSIS, MOLECULAR-WEIGHT PROTEINS, MULTIPLE-MYELOMA, FIBRILLARY GLOMERULONEPHRITIS, RENAL SIGNIFICANCE, PROLIFERATIVE GLOMERULONEPHRITIS, IMMUNOTACTOID GLOMERULOPATHY, SYSTEMIC AMYLOIDOSIS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Multiple myeloma (MM) is one of the most important clonal malignant plasma cell disorders and renal involvement is associated with poor prognosis. Although there are several reasons for renal impairment in MM, the main cause is the toxic effects of monoclonal proteins. Although cast nephropathy is the best known and unchallenged diagnosis for hematologists and pathologists, the renal effects of monoclonal gammopathy can be various. Monoclonal gammopathy of renal significance was proposed by the International Kidney and Monoclonal Gammopathy Research Group for renal lesions in monoclonal gammopathy in recent years. Renal lesions in monoclonal gammopathy can be grouped as follows: light chain (cast) nephropathy, acute tubular injury/necrosis, tubulointerstitial nephritis, amyloidosis, monoclonal Ig deposition diseases, immunotactoid glomerulopathy, type I cryoglobulinemia, proliferative glomerulonephritis with monoclonal IgG deposits, C3 glomerulopathy with monoclonal gammopathy, and crystal-storing histiocytosis, considering the previous and new terminology. In this study, renal involvement of monoclonal gammopathies, in terms of previous and new terminology, was reviewed.