MLL-AF4 gene rearrangement in a child with Epstein-Baff virus-related posttransplant B-cell lymphoma

Corapcioglu F., Olgun N., Sarialioglu F., Uysal K., Oren H., Sercan O.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.25, sa.9, ss.740-742, 2003 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 9
  • Basım Tarihi: 2003
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.740-742
  • Anahtar Kelimeler: Epstein-Barr virus, MLL-AF4 gene rearrangement, posttransplant lymphoproliferative disease, LYMPHOPROLIFERATIVE DISORDERS, RECIPIENTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Recipients of solid organ allografts are known to be at increased risk of developing Epstein-Barr virus-related posttransplant lymphoproliferative diseases. A 28-month-old boy who had received a heterotopic liver transplant presented with lymphadenopathy in the abdomen, multiple nodules in the liver, and bilateral renal infiltration 19 months after transplantation. He was diagnosed with a Burkitt-like lymphoma based on bone marrow examination and the finding that the blastic cells in bone marrow were EBER-1 positive. Cytogenetic analysis of the bone marrow cells showed an MLL-AF4 rearrangement. He was treated with a combined chemotherapy regimen. He has been in continuous complete remission for 15 months now.