Akademik Veri Yönetim Sistemi
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY, cilt.39, sa.2, ss.153-160, 2009 (ESCI)
Collagen crosslinking has been wily used in ectaie disease of the cornea This method causz phoopnlymerisation of the stromal collagen fibers with the combined effecl of the pholosensitizing eubstance riboflavin and ultraviolet A (UVA) beal. After removal of ihe crnic t epithelium ve saturation with riboflavin drops, 3 mW/cm(2) UVA (total 5,4J/cm(2) surface dosage is applied for 30 iinnlure As a re ults of a phocoxijdative miechanis (hat ie desati flationI, inra fibrillary covalent bonds increase After the treatmen new collagen with thicker diameter and esistance to enzymati degradation is formed. By this way, freezing' h stal ri! lagen and ntrease in conical biomechanical stability are aimed, Beside keratocoinus and iantroenic keratectasia. this treatment has been tried for reinforcing ihe effect of intracorneal rings, treat dcnt of coruea I elt moig. uleus keraopathy re hydrops. Immediately after the Irema lt, all-most complete loss of keratocytes in the bateior and mid. stoma and stromal edemna are Sen At the postoperative 3d month, keraoceytes begin to regenerate and edema bepiti to disoappear the cull density increase progressively in the pesioperadve period and around 6th month. tellneroion of the keranxytes is complete, together with the increase in the srmal fiber densicy The mean treatment depth is 320 cm, After treatment in sroma thicker than 400 pmrm, enrt lhe lital damage is not seen Together with the topographic decrease in mean keraiometv stle approximately 25 D decrease in mean spherical equivalent, improvement io nMorplolgical symnmeiry and decrease in corneal abenations were detected.