Topical Diltiazem in the Management of Cutaneous Leiomyoma-Associated Pain: Evaluation With a Cold-Provocation Test.
The Australasian journal of dermatology, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume:
- Publication Date: 2026
- Doi Number: 10.1111/ajd.70060
- Journal Name: The Australasian journal of dermatology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Cutaneous leiomyomas can cause severe pain that may be spontaneous or stimulus-evoked, and is commonly exacerbated by cold exposure, mechanical pressure/touch, or stress. We report a patient with genetically confirmed hereditary leiomyomatosis and renal cell cancer (HLRCC) in whom topical diltiazem 2% was associated with reduced pain, assessed using a controlled cold-provocation test and validated pain scores. This brief report suggests that topical diltiazem may be a useful symptomatic option and supports further evaluation.