TARGETING THE TUMOR METABOLISM BY OXAMATE POTENTIATES THE IMPACT OF CHEMOTHERAPEUTICS IN COLORECTAL CANCER CELLS
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.5, no.3, pp.205-212, 2021 (TRDizin)
- Publication Type: Article / Article
- Volume: 5 Issue: 3
- Publication Date: 2021
- Doi Number: 10.30621/jbachs.988996
- Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
- Journal Indexes: TR DİZİN (ULAKBİM)
- Page Numbers: pp.205-212
- Keywords: Colorectal cancer, tumor metabolism, lactate, sodium oxamate, Warburg effect
- Dokuz Eylül University Affiliated: Yes
Abstract
Purpose: Cancer cells promote lactate formation via pyruvate rather than oxidative phosphorylation by programming their metabolism to maintain proliferation under the Warburg effect. It has shown that the altered metabolic phenotype with activation of lactate dehydrogenase-A in the cancer cell may affect survival, chemotherapy resistance, and metastasis. In this direction, studies are focusing on reprogramming cancer metabolism and increase the effectiveness of chemotherapy. In this study, the main aim was to target the Warburg phenotype via the inhibition of lactate dehydrogenase with the combination of sodium oxamate and current colorectal cancer treatment options such as 5-fluorouracil and irinotecan.