Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study

Chen H., Nicoletti M., Hatch J., Sassi R., Axelson D., Brambilla P., ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.363, sa.1, ss.65-68, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 363 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.neulet.2004.03.042
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.65-68
  • Anahtar Kelimeler: magnetic resonance imaging, bipolar disorder, superior temporal gyrus, adolescents, GRAY-MATTER VOLUME, 1ST-EPISODE SCHIZOPHRENIA, AGE
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Abnormalities in left superior temporal gyrus (STG) have been reported in adult bipolar patients. However, it is not known whether such abnormalities are already present early in the course of this illness. Magnetic resonance imaging (MRI) morphometric analysis of STG was performed in 16 DSM-IV children and adolescents with bipolar disorder (mean age +/- SD 15.5 +/- 3.4 years) and 21 healthy controls (mean age +/- SD 16.9 +/- 3.8 years). Subjects underwent a 3D spoiled gradient recalled acquisition MRI examination. Using analysis of covariance with age, gender and intra-cranial brain volume as covariates, we found significantly smaller left total STG volumes in bipolar patients (12.5 +/- 1.5 cm(3)) compared with healthy controls (13.6 +/- 2.5 cm(3)) (F = 4.45, d.f. = 1, 32, P = 0.04). This difference was accounted for by significantly smaller left and right STG white matter volumes in bipolar patients. Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients. (C) 2004 Elsevier Ireland Ltd. All rights reserved.