COMPARISION OF SERUM HIGH DENSITY LIPOPROTEIN AND SPHINGOSINE-1-PHOSPHATE LEVELS BETWEEN HYPERTENSIVE AND NORMOTENSIVE PREGNANCIES


Creative Commons License

Dilmen E., GÜNYELİ İ., Oral B., ERDEMOĞLU E., GÜNEY M., BAYHAN G., ...More

TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY, no.3, pp.164-168, 2011 (ESCI) identifier

Abstract

Objective: To compare serum high density lipoprotein (HDL) and associated sphingosine-1-phosphate (S1P) levels between hypertensive and normotensive pregnant women and to study likely effect of these parameters on the development of hypertension. Design: A comparative cohort study. Setting: This prospective study was conducted between December 2008 and March 2009 at department of Obstetrics and Gynecology, Suleyman Demirel University, Isparta. Interventions: Plasma S1P and HDL levels were analyzed. Material and methods: S1P levels and HDL levels were analyzed by ELISA. Results: Forty normotensive and 40 hypertensive pregnant women was included to the study. Demographical and obstetrical characteristics of patients were similar. SP1 and HDL levels were 0,6 +/- 0.32 nM and 61.6 +/- 15.3 mg/dl in hypertensive pregnant women. SP1 and HDL levels were 2,1 +/- 10.8 nM and 60.2 +/- 14.4 mg/dl in normotensive pregnant women. There was no statistically significant difference between groups. Conclusion: We concluded that further studies are needed to evaluate the effects of HDL and associated S1P upon the vascular tonus in hypertensive diseases of pregnancies.