Effects of Topical Intranasal Doxycycline Treatment in the Rat Allergic Rhinitis Model

Avincsal M. O., ÖZBAL S., İKİZ A. Ö., PEKÇETİN Ç., GÜNERİ E. A.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, vol.7, no.2, pp.106-111, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.3342/ceo.2014.7.2.106
  • Journal Name: CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.106-111
  • Keywords: Doxycycline, Allergic rhinitis, Matrix metalloproteinase inhibitors, IN-VITRO, METALLOPROTEINASE PRODUCTION, NASAL FIBROBLASTS, UPPER AIRWAYS, EOSINOPHILS, DISEASE, MUCOSA, MATRIX-METALLOPROTEINASE-9, INFLAMMATION, EXPRESSION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives. Allergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and Occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation area by passing through the interstitium and capillary walls. To pass through these barriers, the inflammatory cells degrade extracellular matrix proteins. Matrix metalloproteinases (MMPs) released by inflammatory cells mediate the degradation of these proteins. MMPs have Synthetic inhibitors and doxycycline, a tetracycline antibiotic, inhibits MMPs. This study investigated the efficiency of intranasal doxycycline in decreasing the symptoms and inflammatory cell infiltration in an animal model of AR.