Akademik Veri Yönetim Sistemi
Jinekoloji ve Obstetrik Dergisi, cilt.17, sa.1, ss.20-24, 2003 (Scopus, TRDizin)
OBJECTIVE. Cyclins are a group of proteins that are involved in the control of the entry and progression of proliferating cells through the key checkpoints in the cell cycle. Cyclin D1 protein plays role in the transition of G1-S phase and its overexpression is thought to be related in neoplastic transformation of cells. Apoptosis, programmed cell death, is known to occur in many malignant tumours but its relation to prognosis is not clear and remains to be determined. C-erbB-2 protooncogene encodes a transmembrane glycoprotein which has functional and molecular homology with epidermal growth factor receptor, shows a correlation with poor prognosis. In the present study, we investigated apoptotic index and the expression of cyclin D1 and c-erbB-2 in stage I endometrial carcinomas and their relation to the depth of myometriyal invasion, tumor grade and survival rate. STUDY DESIGN: A total of 60 stage I endometrial carcinomas, with a median follow-up of 29.6 months, were studied. Seven cases (11.6 %) were FIGO stage 1a, 30 (50 %) stage 1b and 23 (38.3 %) stage 1c. Parafin sections were stained with cyclin D1 and c-erbB-2 antibodies using the standard streptavidin-biotin-immunoperoxidase method. Apoptotic index was determined by the rate of apoptotic bodies-cells to vital tumour cells in hematoxylin-eosin stained sections. All these three parameters were correlated with the depth of miyometriyal invasion, grade and survival rate. RESULT (s): No significant relationship was found between cyclin D1, c-erbB-2 expression, apoptotic index and the depth of myometrial invasion, grade and survival rate (p>0.05). CONCLUSION (s): These findings suggest that cyclin D1 and c-erbB-2 expression and apoptotic index are not valuable predictors of myometrial invasion in endometrial carcinomas.