© 2020, TUBITAK. All rights reserved.Historical buildings are important to cultural heritage as they carry their many features to the next generation. These structures are evidence displaying the history, reflecting people's behaviors and culture in the past, as well. The mosques are one of the masterpieces of Islamic culture concerning their structural and architectural properties. The present study focuses on the structural behaviors’ historical masonry buildings in Turkey. The main purpose of this paper is to investigate the structural behavior of the domed mosque and to determine the static and dynamic effects. For this purpose, Afyon Sandıklı Ulu Mosque has been numerically modeled and it has been numerically analyzed. As a result of the analysis, the behavior of the structure under the earthquake effects is obtained. The most affected parts of the structure are determined, and the structural behavior is examined depending on the displacement and stresses over the structure. Finally, assessments on the mosque has been made about the obtained results.