Synthesis, characterization and antioxidant activity of new dibasic tridentate ligands: X-ray crystal structures of DMSO adducts of 1,3-dimethyl-5-acetyl-barbituric acid o-hydroxybenzoyl hydrazone copper(II) complex

GİZİROĞLU E., AYGÜN M., Sarikurkcu C., Kazar D., Orhan N., FIRINCI E., ...Daha Fazla

INORGANIC CHEMISTRY COMMUNICATIONS, cilt.36, ss.199-205, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.inoche.2013.09.013
  • Dergi Adı: INORGANIC CHEMISTRY COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.199-205
  • Anahtar Kelimeler: Hydrazone, Copper(II) complexes, Barbituric acid, Free radical scavenging, FRAP, TRANSITION-METAL-COMPLEXES, BIOLOGICAL-ACTIVITY, BARBITURIC-ACID, IRON CHELATORS, MIXED-LIGAND, SCHIFF-BASES, PD-II, AROYLHYDRAZONES, PHENYLHYDRAZONES, COORDINATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

o-Hydroxybenzoyl hydrazine and p-hydroxybenzoyl hydrazine react with 1,3-dimethyl-5-acetyl-barbituric acid in ethanol to give H2L1 (85% yield) and H2L2 (91% yield) respectively. The copper(II) complexes with DMSO adducts, [Cu(L-1)(DMSO)] and [Cu(L-2)(DMSO)], were prepared by the stoichiometric reaction of the CuCl2 center dot 5H(2)O with the H2L1 and H2L2 in a molar ratio (M:L) of 1:1 in DMSO/water mixture. All compounds have been fully characterized using conventional spectroscopic techniques. X-ray structure analysis was carried out on the [Cu(L-1)(DMSO)] which crystallizes in the triclinic P-1 space group. In addition, both ligands were applied several antioxidant assays including total antioxidant activity by phosphomolybdate, ferric reducing antioxidant power (FRAP) and scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH). The results from antioxidant assays have shown that both ligands have excellent activities. (C) 2013 Elsevier B.V. All rights reserved.