Meibomian Gland Dysfunction in Type 1 Diabetic Patients

Eğrilmez E. D., Altın Ekin M., Duman H. G., Örük G. G., Karadeniz Uğurlu Ş.

4TH INTERNATIONAL MEDICAL CONGRESS OF IZMIR DEMOCRACY UNIVERSITY, 9-11 Aralık 2022, İzmir, İzmir, Türkiye, 9 - 11 Aralık 2022, ss.354, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: İzmir
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.354
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Abstract

Purpose: To investigate meibomian gland and tear film function in patients with type 1 diabetes.

Methods: This prospective study included 50 patients with type 1 diabetes and 50 healthy controls. The

12-item Ocular Surface Disease Index (OSDI) questionnaire was administered to all patients. Both eyes

affected by type 1 diabetes and normal eyes were evaluated and compared with regard to the following

parameters: Tear-film breakup time (TBUT), Schirmer 1 test, area and density scores for corneal

fluorescein staining, eyelid abnormality, meibomian gland expression, meibography scores and areas of

meibomian gland loss.

Results: There were no significant differences in terms of gender and age between groups. The eyes

affected by type 1 diabetes demonstrated significantly lower TBUTs (P<0.001), Schirmer 1 test scores

(P<0.001), and significantly higher eyelid abnormality scores (P<0.001), meibography scores (P<0.001),

and areas of meibomian gland loss in upper eyelid (P<0.001). Diabetic patients with retinopathy had

significantly lower TBUTs (P=0.002) and Schirmer 1 test scores (P=0.018). The duration of diabetes was

significantly positively correlated with meibography scores (P<0.001), and areas of meibomian gland loss

in upper eyelid (P<0.001) and negatively correlated with TBUTs (P<0.001), Schirmer 1 test scores

(P<0.001).

Conclusion: Meibomian gland dysfunction has a significant contribution to the development of dry eye

disease in type 1 diabetic patients. Longer duration of diabetes is associated with changes in meibomian

gland and tear film function.

Keywords: Dry eye; Meibomian gland dysfunction; Type 1 diabetes.