White matter microstructure in patients with obsessive-compulsive disorder

BORA İ. E., Harrison B. J., Fornito A., Cocchi L., Pujol J., Fontenelle L. F., ...Daha Fazla

JOURNAL OF PSYCHIATRY & NEUROSCIENCE, cilt.36, sa.1, ss.42-46, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1503/jpn.100082
  • Dergi Adı: JOURNAL OF PSYCHIATRY & NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.42-46
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.