The effect of dopamine type-2 receptor blockade on autonomic modulation

Kaya D., ELLİDOKUZ E. B., Onrat E., ELLİDOKUZ H., Celik A., Kilit C.

CLINICAL AUTONOMIC RESEARCH, vol.13, no.4, pp.275-280, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1007/s10286-003-0097-3
  • Journal Name: CLINICAL AUTONOMIC RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.275-280
  • Keywords: D2-like receptor, metoclopramide, HRV, sympathovagal balance, HEART-RATE-VARIABILITY, SYMPATHETIC-NERVE ACTIVITY, NOREPINEPHRINE RELEASE, SPECTRAL-ANALYSIS, METOCLOPRAMIDE
  • Dokuz Eylül University Affiliated: No

Abstract

Dopamine2 (D2)-like receptor antagonists are widely used for the treatment of gastroparesis and vomiting. Metoclopramide (MCP), a peripheral and central D2-like receptor antagonist, stimulates the sympathetic nervous system and may alter autonomic modulation, but the net effect of MCP to the heart is not known. The aim of our study was to investigate the effects of MCP on cardiac autonomic modulation, using power spectral analysis of heart rate variability.