Magnetically functionalized molecularly imprinted polymer for curcumin adsorption by experimental design
POLYMER BULLETIN, cilt.80, sa.2, ss.1587-1601, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 80 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.1007/s00289-022-04136-y
- Dergi Adı: POLYMER BULLETIN
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chimica, Compendex, INSPEC
- Sayfa Sayıları: ss.1587-1601
- Anahtar Kelimeler: Curcumin, Molecularly imprinted polymer, Experimental design
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
A molecularly imprinted polymer synthesis parameters for curcumin is optimized by the uniform experimental design method. The polymer is prepared by precipitation polymerization method. In this method, curcumin (CUR), N-isopropylacrylamide (NIPAAM) and 1-vinylimidazole (VI), azobisiobutyronitrile (AIBN) and ethylene glycol dimethacrylate (EGDMA) are used as template, functional monomers, initiator and cross-linker, respectively. The effects of synthesis parameters on the preparation of curcumin-imprinted polymer have been optimized. The effects of the six following parameters are investigated by uniform experimental design. These are the moles of functional monomers (VI, 0.1-1.0 mmol, NIPAAM, 1.0-10.0 mmol), the moles of cross-linker (EGDMA, 5.0-50.0 mmol), amount of initiator (20-100 mg), moles of template (CUR, 0.1-1.0 mmol) and the kind of porogenic solvent (acetonitrile, toluene or DMSO). Additionally, a regression model representing the adsorption capacity (Q) of CUR is developed and validated by variance analysis (ANOVA).