The receptor for advanced glycation end product (RAGE) pathway in COVID-19

Yalcin Kehribar D., Cihangiroglu M., Sehmen E., Avcı B., Capraz A., Yildirim Bilgin A., ...Daha Fazla

Biomarkers, cilt.26, sa.2, ss.114-118, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/1354750x.2020.1861099
  • Dergi Adı: Biomarkers
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.114-118
  • Anahtar Kelimeler: aging, co-morbidity, COVID-19, infection, inflammation, the receptor for advanced glycation end product (RAGE)
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Introduction: Coronavirus disease-2019 (COVID-19) with lung involvement frequently causes morbidity and mortality. Advanced age appears to be the most important risk factor. The receptor for advanced glycation end-product (RAGE) pathway is considered to play important roles in the physiological aging and pathogenesis of lung diseases. This study aimed to investigate the possible relationship between COVID-19 and RAGE pathway. Materials and methods: This study included 23 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed tomography. Serum soluble-RAGE (sRAGE) levels were determined using enzyme-linked immunosorbent assay. Results: The sRAGE levels were significantly higher in the asymptomatic group than in the control group. Age, fibrinogen, C-reactive protein, and ferritin levels were higher and the sRAGE level was lower in the patients with lung involvement than in the asymptomatic patients. Conclusions: In this study, patients with high sRAGE levels were younger and had asymptomatic COVID-19. Patients with low sRAGE levels were elderly patients with lung involvement, which indicates that the RAGE pathway plays an important role in the aggravation of COVID-19.