Akademik Veri Yönetim Sistemi
Congress of the German Society of Radiation Oncology, Leipzig, Almanya, 25 - 27 Haziran 2026, ss.1, (Özet Bildiri)
Fragestellung: Stereotactic body radiotherapy (SBRT) is a definitive treatment for medically
inoperable early-stage NSCLC, providing high local control with low toxicity. We evaluated long-term
outcomes and prognostic factors in our single-institution lung SBRT cohort.
Methodik: We retrospectively analyzed 50 patients with T1–2N0M0 NSCLC treated with SBRT
between 2014 and 2025. Eligible patients had PET/CT staging and were medically inoperable or
refused surgery; diagnoses were confirmed either pathologically or by clinico-radiologic assessment.
Dose fractionation was individualized, with motion management utilizing 4D-CT and daily CBCT. PFS
and OS were estimated using Kaplan–Meier method. Prognostic factors influencing local(LC),
nodal(NC), and distant control(DC) were evaluated using univariate and multivariate analyses with
chi-square and logistic regression tests, respectively.
Ergebnisse: The cohort consisted predominantly of elderly patients (median age, 71 (51-90) years;
30% were ≥75). Most patients were male (66%). Charlson Comorbidity Index (CCI) score was 7 (4-12).
Histological confirmation was unavailable in 56% of patients. The median tumor size was 20 (7–37)
mm, and 76% had T1 disease. SBRT was delivered with a median fraction dose of 10 (7–18) Gy in
median 5 (3–8) fractions over a median RT duration of 12.5 (4–23) days. Median BED10Gy was 100
(85.5–151.2), and median BED3Gy was 216.7 (180–378). Median follow-up was 22 (1-115) months. No
grade 3–4 acute and late toxicity was observed. LC, NC, and DC rates were 96%, 82%, 70%,
respectively. 5-year PFS and OS rates were 36% and 42.8%, respectively. In univariate analyses,
favorable prognostic factors with p<0.1 included: BED10Gy >100 for LC, lower lobe location for NC,
absence of biopsy confirmation, and NC for DC. In multivariate analyses, only NC remained an
independent prognostic factor for DC (p=0.002)
Schlussfolgerung: SBRT provided long-term LC in our cohort with early-stage NSCLC. Patients were
predominantly elderly and/or with comorbidities and thus showed relatively low OS. However, it’s
also crucial to reduce mortality due to distant metastasis. One strategy for DC is to increase NC. Thus,
factors affecting NC warrant further elucidation for optimal results.